Orianna A. Duh, Magy Hanna, Allison Edgar Surgical removal of a complex sensory organ in highly regenerative ctenophores Journal Article In: Journal of Visualized Experimentation, vol. 222, 2025. @article{nokey,
title = {Surgical removal of a complex sensory organ in highly regenerative ctenophores},
author = {Orianna A. Duh, Magy Hanna, Allison Edgar},
url = {https://doi.org/10.3791/67546},
year = {2025},
date = {2025-08-08},
urldate = {2025-08-08},
journal = {Journal of Visualized Experimentation},
volume = {222},
keywords = {Ctenophora, methodology, regeneration},
pubstate = {published},
tppubtype = {article}
}
|
Dorothy Mitchell; Allison Edgar; Júlia Ramon Mateu; Joseph F. Ryan; Mark Q. Martindale The ctenophore Mnemiopsis leidyi deploys a rapid injury response dating back to the last common animal ancestor Journal Article In: Communications Biology, vol. 7, iss. 203, 2024. @article{nokey,
title = {The ctenophore Mnemiopsis leidyi deploys a rapid injury response dating back to the last common animal ancestor},
author = {Dorothy Mitchell and Allison Edgar and J\'{u}lia Ramon Mateu and Joseph F. Ryan and Mark Q. Martindale},
url = {https://doi.org/10.1038/s42003-024-05901-7},
doi = {10.1038/s42003-024-05901-7},
year = {2024},
date = {2024-02-19},
urldate = {2024-02-19},
journal = {Communications Biology},
volume = {7},
issue = {203},
keywords = {Ctenophora, gene regulation, regeneration, whole-body regeneration},
pubstate = {published},
tppubtype = {article}
}
|
Allison Edgar; Dorothy G. Mitchell; Mark Q. Martindale Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi Journal Article In: Genes, vol. 12, iss. 6, pp. 867, 2021. @article{Edgar_2021,
title = {Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi},
author = {Allison Edgar and Dorothy G. Mitchell and Mark Q. Martindale},
url = {https://doi.org/10.3390%2Fgenes12060867},
doi = {10.3390/genes12060867},
year = {2021},
date = {2021-06-01},
urldate = {2021-06-01},
journal = {Genes},
volume = {12},
issue = {6},
pages = {867},
publisher = {MDPI AG},
abstract = {Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration.},
keywords = {Ctenophora, Mnemiopsis leidyi, regeneration},
pubstate = {published},
tppubtype = {article}
}
Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration. |